This paper contains the description of the main challenges and threats which exist or can occur in XXI century, in pragmatic aspect, and at macro scale. Additionally the generated challenges and threats are described on the basic of investigations performed and literature of the subject in a very summarized form, which gives a possibility of broadening their content in every essential dimension. The content of this paper is addressed to the readers who are dealing with the safety problems and to these who will predict the humanity’s development on Earth in her safety dimension.